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hemoglobin F (hereditary persistence of)


Definition: a condition due to an allele that depresses synthesis of ß and ? chains (as in thalassemia), but this is fully compensated by increased ? chain synthesis and there is no anemia; there are 3 types: African type, no ß or ? chain synthesis by the chromosome with the abnormal gene, heterozygotes have 20–30% Hb F and Hb A2 slightly decreased, homozygotes form no Hb A or Hb A2; Greek type, reduced ß and ? chain synthesis, heterozygotes have 10–20% Hb F and normal Hb A2; Swiss type, heterozygotes have only 1 to 3% Hb F and normal Hb A2.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.