Definition: an abnormal Hb with a single ß chain substitution, molecular formula a2Aß226Glu?Lys, common in Southeast Asia, especially Thailand; heterozygotes are asymptomatic with 35–45% Hb E; homozygotes have mild to moderate hemolytic anemia with 90–100% Hb E and the remainder Hb F.
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Examples: glitazone, GI cocktail, etc.