Definition: an abnormal Hb with a single ß chain substitution, molecular formula a2Aß2121Glu?Gln; heterozygotes are asymptomatic, homozygotes have mild hemolytic anemia; there is an increase in O2 affinity; identical to hemoglobin DLos Angeles, hemoglobin DNorth Carolina, hemoglobin DPortugal, hemoglobin DChicago, and hemoblogin Oak Ridge.
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Examples: glitazone, GI cocktail, etc.