- The upper or anterior extremity of the animal body, containing the brain and the organs of sight, hearing, taste, and smell.
- The upper, anterior, or larger extremity, expanded or rounded, of any body, organ, or other anatomic structure.
- The rounded extremity of a bone.
- That end of a muscle that is attached to the less movable part of the skeleton.
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Examples: glitazone, GI cocktail, etc.