Pronunciation: har'de win'berg
Definition: if mating occurs at random with respect to any one autosomal locus in a population in which the gene frequencies are equal in the two sexes, and the factors tending to change gene frequencies (mutation, differential selection, migration) are either absent or negligible, then in one generation the probabilities of all possible genotypes will on average equal the same proportions as if the genes were assembled at random. The law does not apply to two or more loci jointly, nor to X-linked traits where the initial gene frequencies differ in the two sexes.
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Examples: glitazone, GI cocktail, etc.