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gumma

Pronunciation: gum'a, a-ta, -ez

Definition: An infectious granuloma that is characteristic of tertiary syphilis, but does not always develop, and that may be solitary (as large as 8–10 cm in diameter) or multiple and diffusely scattered (1 mm or less in diameter). Gummata are characterized by an irregular central portion that is firm, sometimes partially hyalinized, and consisting of coagulative necrosis in which “ghosts” of structures may be recognized; a poorly defined middle zone of epithelioid cells, with occasional multinucleated giant cells; and a peripheral zone of fibroblasts and numerous capillaries, with infiltrated lymphocytes and plasma cells. As gummas become older, an irregular scar or rounded fibrous nodule persists.

Synonym(s): syphiloma

[L. gummi, gum, fr. G. kommi]

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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