Definition: a form of leukemia characterized by an uncontrolled proliferation of myelopoietic cells in the bone marrow and in extramedullary sites, and the presence of large numbers of immature and mature granulocytic forms in various tissues (and organs) and in the circulating blood; the total count may range from 1000 (aleukemic variety) to several hundred thousand per mm3. The predominant cell is usually of the neutrophilic series, but, in a few instances, eosinophilic or basophilic granulocytes, or even megakaryocytes, may represent the chief form; early in granulocytic leukemia, the circulating blood may contain excessive numbers of all of the granulocytic forms.
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