Definition: An enzyme, lactoylglutathione lyase (g. I) or hydroxyacylglutathione hydrolase (g. II), in erythrocytes and other tissues that converts glyoxal and substituted glyoxals bound to glutathione into the corresponding free hydroxy acids (g. II) or glyoxals (g. I).
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Examples: glitazone, GI cocktail, etc.