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Medical Term:

glycosylphosphatidyliositol anchor

Pronunciation: glī′kō-sil-fos-fă-tī′dil-ī-os′i-tal ang′kŏr

Definition: a tether for some surface proteins to the cell membrane; these proteins are deficient in blood cells of patients with paroxysmal nocturnal hemoglobinuria as a result in a mutation in the X-linked phosphatidylinositolglycan complementation group A gene; GPI-linked proteins are required for normal lymphocyte function and to maintain normal peripheral lymphoid homeostasis.

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