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glycoprotein IIb/IIIa


Definition: A fibrinogen and von Willebrand factor receptor of the integrin family that plays a key role in platelet activation. Inhibitors of this protein complex are used as pharmacologic agents to prevent platelet activation and thrombosis. Deficiency of this complex results in Glanzmann thrombasthenia.

Synonym(s): integrin alpha2b-beta3, CD41/CD61

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.