glycine cleavage complex
a complex of several proteins that catalyze the reversible reaction of glycine with tetrahydrofolate to produce CO2, NH3, and N5,N10-methylenetetrahydrofolate; a deficiency of this enzyme (or one of its subunits) will result in nonketotic hyperglycinemia.
Synonym(s): glycine synthase
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Examples: glitazone, GI cocktail, etc.