Pronunciation: glu'kos fos'fat de'hi-droj'en-as
An NADP+-dependent enzyme catalyzing the dehydrogenation of d-glucose 6-phosphate to 6-phospho-d-glucono-d-lactone, this reaction initiating the pentose shunt. A deficiency of this enzyme can lead to severe hemolytic anemia and favism. A deficiency of the leukocyte enzyme prevents respiratory burst in neutrophils.
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Examples: glitazone, GI cocktail, etc.