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glucose-6-phosphate dehydrogenase

Pronunciation: glu'kos fos'fat de'hi-droj'en-as

Definition: An NADP+-dependent enzyme catalyzing the dehydrogenation of d-glucose 6-phosphate to 6-phospho-d-glucono-d-lactone, this reaction initiating the pentose shunt. A deficiency of this enzyme can lead to severe hemolytic anemia and favism. A deficiency of the leukocyte enzyme prevents respiratory burst in neutrophils.

Synonym(s): Robison ester dehydrogenase, Zwischenferment

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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