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Medical Term:

glucose-6-phosphate dehydrogenase

Pronunciation: glū′kōs fos′fāt dē′hī-droj′en-ās

Definition: An NADP+-dependent enzyme catalyzing the dehydrogenation of d-glucose 6-phosphate to 6-phospho-d-glucono-΄-lactone, this reaction initiating the pentose shunt. A deficiency of this enzyme can lead to severe hemolytic anemia and favism. A deficiency of the leukocyte enzyme prevents respiratory burst in neutrophils.

Synonym(s): Robison ester dehydrogenase, Zwischenferment