generalized Shwartzman phenomenon
Definition: when both the primary injection of endotoxin-containing filtrate and the secondary injection are given intravenously 24 hours apart, the animal usually dies within 24 hours after the second inoculation; the characteristic lesions in the rabbit include widespread hemorrhages in the lung, liver, and other organs and bilateral cortical necrosis of the kidney. This reaction has no immunologic basis.
© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.