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generalized Shwartzman phenomenon

Pronunciation: shwarts'man

Definition: when both the primary injection of endotoxin-containing filtrate and the secondary injection are given intravenously 24 hours apart, the animal usually dies within 24 hours after the second inoculation; the characteristic lesions in the rabbit include widespread hemorrhages in the lung, liver, and other organs and bilateral cortical necrosis of the kidney. This reaction has no immunologic basis.

Synonym(s): Sanarelli phenomenon, Sanarelli-Shwartzman phenomenon

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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