Definition: large, finely and uniformly vacuolated cells derived from the reticuloendothelial system, and found especially in the spleen, lymph nodes, liver, and bone marrow of patients with Gaucher disease; Gaucher cells contain kerasin (a cerebroside), which accumulates as a result of a genetically determined absence of the enzyme glucosylceramidase.
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Examples: glitazone, GI cocktail, etc.