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Gaucher cells

Pronunciation: gō-shā′

Definition: large, finely and uniformly vacuolated cells derived from the reticuloendothelial system, and found especially in the spleen, lymph nodes, liver, and bone marrow of patients with Gaucher disease; Gaucher cells contain kerasin (a cerebroside), which accumulates as a result of a genetically determined absence of the enzyme glucosylceramidase.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.