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Pronunciation: gang'gle-o-si-do'sis

Definition: Any disease characterized, in part, by the abnormal accumulation within the nervous system of specific gangliosides, GM2 gangliosidosis, Tay-Sachs disease; caused by hexosaminidase A enzyme deficiency with accumulation of GM2 ganglioside.

Synonym(s): gangliosialidosis, ganglioside lipidosis

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.