Definition: a form of chronic splenomegaly characterized by conspicuous thickening of the capsule and the presence of multiple, small, rustlike, brown foci (Gamna-Gandy bodies), which contain iron; this condition may be observed in fibrocongestive splenomegaly, sickle cell disease, and some examples of hemochromatosis.
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Examples: glitazone, GI cocktail, etc.