Pronunciation: fruk'tos bis-fos'fa-tas
Definition: A hydrolase that catalyzes conversion of fructose 1,6-bisphosphate to d-fructose 6-phosphate and orthophosphate in gluconeogenesis; AMP is an allosteric inhibitor; fructose-bisphosphatase deficiency results in problems with impaired gluconeogenesis; there is a similar enzyme that acts on fructose 2,6-bisphosphate.
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Examples: glitazone, GI cocktail, etc.