Framingham Heart Study
the first major U.S. study of the epidemiology of cardiovascular disease, begun in Framingham, Massachusetts, in 1948 under the auspices of the National Heart Institute (now the National Heart, Lung, and Blood Institute) and still in operation. Initially the Framingham researchers enrolled 5209 men and women between the ages of 30 and 60 to study the evolution of heart disease and identify risk factors for heart attack. In 1971, the Framingham Offspring Study enrolled 5,124 adult children of original study participants along with their spouses, and in 2001 the Third Generation Study recruited some 3,500 grandchildren of original enrollees.
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