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frameshift

Pronunciation: fram'shift

Definition: As used in genetics, a mutation that causes a sequence such that the reading frame groups of three bases in mRNA become out of register; the insertion or deletion of one or two bases, for example, would lead to an altered grouping of three bases causing incorrect amino acid residues to be incorporated into growing polypeptide chains, or would signal premature chain termination.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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