fluorescence in situ hybridization
technique and adjunct method in cytogenetic analysis whereby a DNA probe is labeled with fluorescent dye and applied to interphase nuclei, binding to its complementary sequence and labeling a specific chromosome, which can then be visualized using a fluorescent microscope. FISH can show complex translocations and subtle deletions that are not readily discovered by routine karyotyping.
Search Stedman's Medical Dictionary
Examples: glitazone, GI cocktail, etc.