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Medical Term:

fluorescence in situ hybridization


Definition: technique and adjunct method in cytogenetic analysis whereby a DNA probe is labeled with fluorescent dye and applied to interphase nuclei, binding to its complementary sequence and labeling a specific chromosome, which can then be visualized using a fluorescent microscope. FISH can show complex translocations and subtle deletions that are not readily discovered by routine karyotyping.

© Copyright 2016 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.