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fluorescence in situ hybridization

 

Definition: technique and adjunct method in cytogenetic analysis whereby a DNA probe is labeled with fluorescent dye and applied to interphase nuclei, binding to its complementary sequence and labeling a specific chromosome, which can then be visualized using a fluorescent microscope. FISH can show complex translocations and subtle deletions that are not readily discovered by routine karyotyping.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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