Definition: the intestinal and hepatic degradation or alteration of a drug or substance taken by mouth, after absorption, removing some of the active substance from the blood before it enters the general circulation.
Synonym(s): first-pass effect
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
© Copyright 2019 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.