Definition: Presence of filariae in the tissues of the body or in blood (microfilaremia) or tissue fluids (microfilariasis), occurring in tropic and subtropic regions; living worms cause minimal tissue reaction, which may be asymptomatic, but death of the adult worms leads to granulomatous inflammation and permanent fibrosis causing obstruction of the lymphatic channels from dense hyalinized scars in the subcutaneous tissues; the most serious consequence is elephantiasis or pachyderma.
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