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Definition: A protein that inhibits ectopic calcification of blood vessels and organs. The serum protein was originally described as the major globulin in fetal and newborn calf. It is an abundant serum protein in mammalian species and in humans; it is expressed in the adult liver and in many organs during embryogenesis. Preliminary data suggest that low levels of fetuin-A are associated with mortality in patients with end-stage kidney disease, who are at particular risk for atherosclerosis and cardiovascular risk.

Synonym(s): a2-Heremans Schmid glycoprotein, AHSG, alpha-HS-glycoprotein

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.