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factor XI


Definition: in the clotting of blood, also known as plasma thromboplastin antecedent, a component of the contact system that is absorbed from plasma and serum by glass and similar surfaces. Its active form, factor XIa (EC, is a serine proteinase converting factor IX to factor IXa. Deficiency of factor XI results in a hemorrhagic tendency; is caused by an autosomal recessive gene.

Synonym(s): plasma thromboplastin antecedent

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.