Definition: in the clotting of blood, also known as: Christmas factor (Biggs and Macfarlane), plasma thromboplastin component (Aggeler), antihemophilic globulin B (Cramer), plasma thromboplastin factor B (Aggeler), plasma factor X (Shulman), antihemophilic factor B, and platelet cofactor II. Factor IX is required for the formation of intrinsic blood thromboplastin and affects the amount formed (rather than the rate). Its active form, factor IXa (EC 188.8.131.52) is a serine proteinase converting factor X to factor Xa by cleaving an arginine-isoleucine bond. Deficiency of factor IX causes hemophilia B.
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