Pronunciation: es-tra-di'ol, es-tra'de-ol
Definition: the most potent naturally occurring estrogen in mammals, formed by the ovary, placenta, testis, and possibly the adrenal cortex; therapeutic indications for estradiol are those typical of an estrogen. a-Estradiol (17a-estradiol), exhibits considerably less biologic activity.
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Examples: glitazone, GI cocktail, etc.