Definition: a grave hemolytic anemia that, in most instances, results from development in an Rh-negative mother of anti-Rh antibody in response to the Rh factor in the (Rh-positive) fetal blood; it is characterized by many erythroblasts in the circulation, and often generalized edema (hydrops fetalis) and enlargement of the liver and spleen; the disease is sometimes caused by antibodies for antigens other than Rh.
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