Definition: a neoplastic process involving the erythropoietic tissue, characterized by anemia, irregular fever, splenomegaly, hepatomegaly, hemorrhagic disorders, and numerous erythroblasts in all stages of maturation (with disproportionately large numbers of less mature forms) in the circulating blood; postmortem studies reveal primitive erythroblasts and reticuloendothelial cells, not only in hemopoietic organs, but also in the kidneys, adrenal glands, and other sites. Acute and chronic forms are recognized, but in the latter there is less prominence of the immature cells; the former is also called Di Guglielmo disease (or syndrome) and acute erythremia.
Synonym(s): Di Guglielmo disease
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