Definition: an acute eruption of macules, papules, or subepidermal vesicles presenting a multiform appearance, the characteristic lesion being the target or iris lesion over the dorsal aspect of the hands and forearms; its origin may be allergic, including drug sensitivity, or it may be caused by herpes simplex infection; the eruption, although usually self-limited (multiforme minor), may be recurrent or may run a severe course, sometimes with fatal termination (multiforme major or Stevens-Johnson syndrome).
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Examples: glitazone, GI cocktail, etc.