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epinephrine reversal


Definition: the fall in blood pressure produced by epinephrine when given following blockage of a-adrenergic receptors by an appropriate drug such as phenoxybenzamine; the vasodilation reflects the ability of epinephrine to activate ß-adrenergic receptors that, in vascular smooth muscle, are inhibitory; in the absence of a-receptor blockade, the ß-receptor activation by epinephrine is masked by its predominant action on vascular a-receptors, which causes vasoconstriction.

Synonym(s): adrenaline reversal

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.