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Medical Term:

epinephrine reversal


Definition: the fall in blood pressure produced by epinephrine when given following blockage of α-adrenergic receptors by an appropriate drug such as phenoxybenzamine; the vasodilation reflects the ability of epinephrine to activate β-adrenergic receptors that, in vascular smooth muscle, are inhibitory; in the absence of α-receptor blockade, the β-receptor activation by epinephrine is masked by its predominant action on vascular α-receptors, which causes vasoconstriction.

Synonym(s): adrenaline reversal