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eosinophilia-myalgia syndrome

 

Definition: a probable autoimmune disorder precipitated by contaminated l-tryptophan tablets; characterized by fatigue, low-grade fever, myalgias, muscle tenderness and cramps, weakness, paresthesias of the extremities, and skin indurations; marked eosinophilia is noted on peripheral blood studies, serum aldolase is increased, and biopsies of peripheral nerve, muscle, skin, and fascia show microangiopathy and inflammation in connective tissue.

Synonym(s): E-M syndrome

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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