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endogenous pyrogen


Definition: proteins that induce fever. Several (about 11) have been identified, including cytokines formed by components of the immune system, especially macrophages (interleukins 1 and 6, interferons, and tumor necrosis factors).

Synonym(s): leukocytic pyrogens

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.