Definition: The innermost of the three primary germ layers of the embryo (ectoderm, mesoderm, endoderm); from it is derived the epithelial lining of the primordial gut and the epithelial component of the glands and other structures (lower respiratory system) that develop as outgrowths from the gut.
[endo- + G. derma, skin]
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Examples: glitazone, GI cocktail, etc.