Definition: the difference between the amount of diphtheria toxin that will exactly neutralize 1 U of antitoxin and that which, added to 1 U of antitoxin, will leave one lethal dose free is greater than one lethal dose of toxin; it is necessary to add more than one lethal dose of toxin to a neutral mixture of toxin and antitoxin to make the mixture lethal (the basis of the L+ dose).
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Examples: glitazone, GI cocktail, etc.