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Pronunciation: eks'ta-se


  1. The popular name for 304 methylenedioxymethamphetamine.
  2. A drug of abuse, used at clubs, raves, and rock concerts. This agent was first synthesized in Germany in the early 1900s and used during World War I to induce soldiers to charge from the line of trenches into the line of fire. It acts acutely to increase energy, provide a sense of camaraderie and attachment, increase sexual desire, and induce euphoria. Besides sexual side effects, produces increased heart rate, chills, seating, dehyration, and various strictly psychiatric symptoms. Dosages not much higher than recreational amounts can be toxic to serotonergic and other neurons. Long-term use associated with changes in serotonergic neurons may predispose an abuser to long-term psychiatric symptoms.
  3. Mental exaltation, and/or a rapturous experience.
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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.