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Medical Term:

down-regulation

Pronunciation: down-reg'yu-la'shun

Definition: Development of a refractory or tolerant state consequent on repeated administration of a pharmacologically or physiologically active substance; often accompanied by an initial decrease in affinity of receptors for the agent and a subsequent diminution in the number of receptors.

© Copyright 2016 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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