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Medical Term:

dihydropyrimidine dehydrogenase

Pronunciation: di-hi'dro-pi-rim'i-den de-hi'dro-jen-as'

Definition: An enzyme in pyrimidine biosynthesis that reacts 5,6-dihydrouracil with NADP+ to form uracil and NADPH; it also acts on dihydrothymine; a deficiency of this enzyme can result in hyperuracil thyminuria.

Synonym(s): dihydrouracil dehydrogenase

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