Pronunciation: di-hi'dro-lip-o-am'id de-hi'dro-jen-as'
A flavoenzyme oxidizing dihydrolipoamide at the expense of NAD+; completes the oxidative decarboxylation of pyruvate; a part of several enzyme complexes (a-ketoglutarate dehydrogenase complex). Decreased activity leads to neuronal loss in brain resulting in psychomotor retardation.
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Examples: glitazone, GI cocktail, etc.