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dihydrofolate reductase

Pronunciation: di-hi'dro-fo'lat re-duk'tas

Definition: An enzyme reversibly oxidizing tetrahydrofolate to 7,8-dihydrofolate with NADP+. A crucial enzyme in one-carbon metabolism; used as a marker of drug resistance to methotrexate.

Synonym(s): 5,6,7,8-tetrahydrofolate dehydrogenase

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.