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diffuse Lewy body disease

Pronunciation: la've

Definition: a degenerative cerebral disorder of the elderly, characterized initially by progressive dementia or psychosis, and subsequently by parkinsonian findings, usually with severe rigidity; other manifestations include involuntary movements, myoclonus, dysphagia, and orthostatic hypotension. Pathologically, Lewy bodies are present diffusely in the nuclei of the hypothalamus, basal forebrain, and brainstem.

Synonym(s): Lewy body dementia

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.