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deoxyribonuclease I

 

Definition: an endonuclease that cleaves primarily double-stranded DNA to a mixture of oligodeoxyribonucleotides, each ending in a 5'-phosphate; streptodornase is a similar enzyme. Under appropriate conditions, it can produce single-strand nicks in DNA; used in nick translation and in the mapping of hypersensitive sites.

Synonym(s): pancreatic deoxyribonuclease, thymonuclease

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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