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Medical Term:

deoxyribonuclease I

 

Definition: an endonuclease that cleaves primarily double-stranded DNA to a mixture of oligodeoxyribonucleotides, each ending in a 5'-phosphate; streptodornase is a similar enzyme. Under appropriate conditions, it can produce single-strand nicks in DNA; used in nick translation and in the mapping of hypersensitive sites.

Synonym(s): pancreatic deoxyribonuclease, thymonuclease

© Copyright 2016 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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