Pronunciation: de-mi'e-lin-a'shun, de-mi'e-lin-i-za'shun
Loss of myelin with preservation of the axons or fiber tracts. Central demyelination occurs within the central nervous system (the demyelination seen with multiple sclerosis); peripheral demyelination affects the peripheral nervous system (the demyelination seen with Guillain-Barré syndrome).
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Examples: glitazone, GI cocktail, etc.