Definition: A subclass of lyases (hydro-lyases) that remove H and OH as H2O from a substrate, leaving a double bond, or add a group to a double bond by the elimination of water from two substances to form a third; synthase is sometimes used when the synthetic aspect of the reaction is emphasized. Some trivial names of enzymes in this subclass bear the generic term hydratase, emphasizing the reverse reaction.
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Examples: glitazone, GI cocktail, etc.