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death pathway


Definition: finding that characterizes a protein that initiates final stage of cell death known as apoptosis. Mammalian families of proteins that execute the apoptotic pathway are Bcl-2, Apaf-1, and caspase-3. FAS receptor-ligand system is a regulator of apoptotic cell death.

Synonym(s): cell-death pathway

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.