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cytotoxic reaction

 

Definition: an immunologic (allergic) reaction in which noncytotropic IgG or IgM antibody combines with specific antigen on cell surfaces; the resulting complex initiates the activation of complement, which causes cell lysis or other damage, or which, in the absence of complement, may lead to phagocytosis or enhance T-lymphocyte involvement leading to cellular cytotoxicity.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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