cytochrome c oxidase
Pronunciation: si'to-krom oks'i-das
Definition: A cupriferous cytochrome of the a type that catalyzes the oxidation of four molecules of ferrocytochrome c by molecular oxygen to produce four molecules of ferricytochrome c and 2H2O. A part of Complex IV of the respiratory chain. A deficiency of one or more of the polypeptides of this complex results in neuronal loss in the brain leading to psychomotor retardation and neurodegenerative disease.
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Examples: glitazone, GI cocktail, etc.