cytochrome b5 reductase
Pronunciation: si'to-krom re-duk'tas
Definition: A flavoenzyme catalyzing the reduction of two molecules of ferricytochrome b5 to two molecules of ferrocytochrome b5 at the expense of NADH; has a role in fatty acid desaturation; a deficiency can lead to hereditary methemoglobinemia (type I, only observed in erythrocyte cytosol; type II, deficiency in all tissues; type III, deficiency in all hematopoetic cells).
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Examples: glitazone, GI cocktail, etc.