Skip to Content



Definition: a cytochrome P450 isoform found in the gastrointestinal tract as well as hepatic and other cells; substrates include benzodiazepines, calcium channel blockers, antihistamines, steroid hormones, and protease inhibitors. Inhibited by antidepressants, azole antifungals, cimetidine, grapefruit juice, and erythromycin. Induced by phenobarbital, phenytoin, rifampin, and carbamazepine.

Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.
© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.