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CYP 3A

 

Definition: a cytochrome P450 isoform found in the gastrointestinal tract as well as hepatic and other cells; substrates include benzodiazepines, calcium channel blockers, antihistamines, steroid hormones, and protease inhibitors. Inhibited by antidepressants, azole antifungals, cimetidine, grapefruit juice, and erythromycin. Induced by phenobarbital, phenytoin, rifampin, and carbamazepine.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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