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Pronunciation: si'klo-fil'inz

Definition: Intracellular proteins associated with heat shock proteins and other molecules (e.g., glucocorticoid receptors). Cyclophilins mediate immunosuppressive actions of antirejection drugs (e.g., cyclosporine and FK-506).

[cyclo- + G. philia, love, attraction, + -in]

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.