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Medical Term:


Pronunciation: kri'o-glob'yu-linz


  1. Abnormal plasma proteins (paraproteins), now grouped with gamma globulins, characterized by precipitating, gelling, or crystallizing when serum or solutions of them are cooled; distinguished from Bence Jones proteins by their larger molecular weight (approximately 200,000 compared with 35,000–50,000); they may appear in patients with multiple myeloma.
  2. Any globulin that forms a gel or flocculent precipitate on cooling.
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